The Science

The Science Behind Methylene Blue

A molecule with a history — and a future.
Originally developed in the 19th century as a textile dye, methylene blue has since been studied extensively for its applications in cellular and mitochondrial health. Its powerful redox properties make it a compound of growing interest across neuroscience, longevity research, and cellular energy studies.

How It Works: Mitochondrial Support

Methylene blue acts as an electron cycler, meaning it can shuttle electrons within the mitochondria — your body’s energy powerhouses. This helps improve the efficiency of ATP production, especially under oxidative stress.

  • Supports mitochondrial respiration
  • Reduces reactive oxygen species (ROS)
  • Promotes cellular resilience

In essence, methylene blue may help your cells make energy more efficiently while protecting against cellular stress.

Cognitive Function & Neuroprotection

Peer-reviewed studies have suggested that low doses of methylene blue may enhance memory consolidation, working memory, and cerebral oxygenation.

  • It has been explored as a nootropic compound due to its impact on:
  • Mitochondrial energy in brain cells
  • Potential protective effects against neurodegeneration
  • Mental clarity and processing speed

Dosage in Research Contexts

While our product is for research purposes only, here are references from peer-reviewed literature:

  • ~0.5 mg/kg is a common dosage explored in cognitive and mitochondrial studies
  • 10 drops of a 2% solution = approx. 10 mg of methylene blue
  • Research-grade applications have used doses ranging from 0.25–4 mg/kg

Safety & Considerations

Contraindications:
Methylene blue should not be used in combination with SSRIs, MAOIs, or SNRIs, and is contraindicated in individuals with G6PD deficiency.

Disclaimer:
This product is not intended to diagnose, treat, cure, or prevent any disease. For laboratory, research, or external use only. Not for therapeutic use. Always consult a medical professional before handling.

Further Reading

Want to explore more? Here are a few foundational studies and reviews:

  • “Methylene Blue as a Nootropic Agent: Review of Mechanisms” – Journal of Neural Transmission - PDF
  • “Methylene Blue and Mitochondrial Function” – Frontiers in Aging Neuroscience - PDF
  • “Cognitive Enhancement in Human Trials Using MB” – Neuropharmacology - PDF